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M94A3004.TXT
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1994-10-25
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Document 3004
DOCN M94A3004
TI Under-reporting of AIDS-associated Kaposi's sarcoma (KS) and
non-Hodgkin's lymphomas (NHL).
DT 9412
AU Serraino D; Franceschi S; Dal Maso L; Rezza G; Vaccher E; Tirelli U;
Division of Epidemiology, Aviano Cancer Centre, Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):175 (abstract no. PB0127). Unique
Identifier : AIDSLINE ICA10/94369571
AB OBJECTIVE: Since AIDS surveillance data tend to underestimate the
prevalence of AIDS-associated KS and NHL, this study was aimed at
quantifing the degree of under-reporting of such neoplasms in the
Italian AIDS surveillance scheme (RAIDS). METHODS: A linkage study
between the Italian Cooperative Group on AIDS-related Tumours (GICAT, a
voluntary reporting system for HIV-infected patients who develop cancer)
and the mandatory notifications of AIDS cases to the RAIDS was carried
out. Thus, 288 cases of AIDS-associated KS and 258 cases of NHL
fulfilling the AIDS definition criteria were matched with the totality
of 16,860 AIDS cases reported to the RAIDS up to March 1993. RESULTS:
28% of the 288 diagnoses of AIDS-associated KS made by the GICAT centres
were not reported to the RAIDS (4% because of lack of case notification;
17% due to lack of follow-up information and 7% because of lack of
neoplastic diagnosis reporting). As concerns the 258 NHL, 40% of these
neoplasms did not appear among the clinical manifestations of AIDS (7%
due to lack of case notification; 24% because of lack of follow-up
information and 9% because of lack of neoplastic diagnosis reporting).
DISCUSSION AND CONCLUSIONS: These results indicate that the prevalence
of AIDS-associated KS and NHL is substantially underestimated by AIDS
surveillance data and that their impact on morbidity and mortality rates
of AIDS cases is much higher than previously reported. The validation of
AIDS surveillance data with other sources of oncological information is
of crucial importance to better estimate the burden of AIDS-related
tumours and to study the interaction between HIV infection and cancer.
DE Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY Bias (Epidemiology)
Comorbidity Cross-Sectional Studies Female Human Incidence
Italy/EPIDEMIOLOGY Lymphoma, AIDS-Related/*EPIDEMIOLOGY Male
*Population Surveillance Sarcoma, Kaposi's/*EPIDEMIOLOGY Skin
Neoplasms/*EPIDEMIOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).